Enhancing the Pharmaceutical Properties of Flavonoids via Methylation and Glycosylation
نویسنده
چکیده
analogues is true as exemplified by the studies focused upon the use of sugar conjugation: glycosylated compounds can greatly enhance drug solubility (upto >2 folds) and enhance uptake in vitro [7]. As the motive in various modifications of flavonoids is to increase the stability and biological activity, and most of the glycosylated products showed only the increase in solubility and lack of prominent biological activity, we recently focused our research direction towards the methylation of these pharmaceutically significant flavonoids.
منابع مشابه
Methylation and Subsequent Glycosylation of Flavonoids: Koirala Effect
Flavonoids are ubiquitous plant secondary metabolites and have been recognized to be potent pharmaceutical agents by several research groups. Methylation of the flavonoids via theirs frees hydroxyl groups or carbon atom dramatically increases their metabolic stability and enhances the membrane transport, leading to facilitated absorption and greatly increased oral bioavailability. Glycosylation...
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